Journal:

Article Title: In Vitro Activities of Garenoxacin and Levofloxacin against Chlamydia pneumoniae Are Not Affected by Presence of Mycoplasma DNA

doi: 10.1128/AAC.48.6.2081-2084.2004

Figure Lengend Snippet: Susceptibilities of 20 C. pneumoniae isolates to garenoxacin and levofloxacin and presence of Mycoplasma DNA in C. pneumoniae cultures from three sources

Article Snippet: There was no evidence that the presence of Mycoplasma sp. DNA affected the results of antimicrobial agent susceptibility testing with C. pneumoniae . table ft1 table-wrap mode="anchored" t5 TABLE 1. caption a7 Isolate a Source Site Garenoxacin b Levofloxacin c Mycoplasma DNA MIC (μg/ml) MBC (μg/ml) MIC (μg/ml) MBC (μg/ml) 53592 (AR-39) ATCC Throat 0.015 0.015 0.5 0.5 − VR-1310 ATCC Throat 0.03 0.03 0.5 0.5 − VR-1360 ATCC Sputum 0.03 0.03 0.5 0.5 + VR-1356 ATCC Nasopharynx 0.03 0.125 1.0 2.0 + VR-2282 ATCC Conjunctiva 0.015 0.03 0.5 0.5 + VR-1435 ATCC Throat 0.015 0.015 0.5 0.5 + VR-1355 ATCC Nasopharynx 0.03 0.03 0.5 0.5 + VR-1452 ATCC Atheroma 0.03 0.03 0.5 0.5 + A03SEG U. d Louisville Atheroma 0.015 0.015 0.5 0.5 + AR388 U. Washington Throat 0.03 0.03 0.5 0.5 + AR277 U. Washington Throat 0.03 0.03 0.5 1.0 + AR231 U. Washington Throat 0.03 0.03 0.5 1.0 + AR427 U. Washington Throat 0.06 0.06 2.0 4.0 + LR65 U. Washington Throat 0.06 0.06 2.0 4.0 + Ka50 U. Washington Throat 0.06 0.06 1.0 1.0 + Ka66 U. Washington Throat 0.015 0.015 0.5 0.5 + AC14 U. Washington Throat 0.03 0.03 2.0 2.0 + AC51 U. Washington Throat 0.015 0.015 1.0 1.0 + ER115 U. Washington Throat 0.015 0.015 0.5 1.0 − AR458 U. Washington Throat 0.03 0.03 2.0 2.0 + Open in a separate window a All isolates except Ka50, Ka66, AC14, and AC51 were originally from the United States; isolates Ka50 and Ka66 were originally from Finland, and isolates AC14 and AC51 were originally from Japan. b The MIC 50 , MIC 90 , and MIC range for garenoxacin are 0.03, 0.06, and 0.015 to 0.06 μg/ml, respectively; the MBC 50 , MBC 90 , and MBC range for garenoxacin are 0.03, 0.06, and 0.015 to 0.125 μg/ml, respectively. c The MIC 50 , MIC 90 and MIC range for levofloxacin are 0.5, 2.0, and 0.5 to 2.0 μg/ml, respectively; the MBC 50 , MBC 90 , and MBC range for levofloxacin are 0.5, 2.0, and 0.5 to 4.0 μg/ml, respectively. d U., University of. Susceptibilities of 20 C. pneumoniae isolates to garenoxacin and levofloxacin and presence of Mycoplasma DNA in C. pneumoniae cultures from three sources Table shows the identities (determined by comparison of the sequences of the 16S rRNA gene PCR amplicons with the sequences in the GenBank and NCBI databases) of the Mycoplasma spp. found in cultures of five of the C. pneumoniae isolates used in this study.

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